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Two new acorane sesquiterpenes from Illicium henryi

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成果类型:
期刊论文
作者:
Song, Tai-Fa;Zhang, Wei-Dong;Xia, Xin-Hua;Shen, Yun-Heng;Liu, Chun-Mei;...
通讯作者:
Li, Hui-Liang
作者机构:
[Lin, Sheng; Song, Tai-Fa; Liu, Chun-Mei; Zhang, Wei-Dong; Li, Hui-Liang; Shen, Yun-Heng] Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China.
[Zhang, Wei-Dong; Jin, Hui-zi] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China.
[Song, Tai-Fa; Xia, Xin-Hua] Hunan Univ TCM, Dept Pharmaceut, Sch Pharm, Changsha 410007, Hunan, Peoples R China.
通讯机构:
[Li, Hui-Liang] S
Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China.
语种:
英文
关键词:
Illicium henryi;Acorane sesquiterpenes;NO production
期刊:
Archives of Pharmacal Research
ISSN:
0253-6269
年:
2009
卷:
32
期:
9
页码:
1233-1236
基金类别:
The work was partially supported by the National Natural Science Foundation of China (30725045), National 863 Program (2006AA02Z338), “973” program of China (2007CB507400), Shanghai Leading Academic Discipline Project (B906) and in part by the Scientific Foundation of Shanghai China (07DZ19728, 06DZ19717, 06DZ19005). We acknowledge the Pharmaceutical Analysis Center of Second Milliterary Medical University for measuring the IR and NMR spectra.
机构署名:
本校为其他机构
院系归属:
药学院
摘要:
Two new acorane sesquiterpenes, 10-hydroxyacoronene (1) and 1β-isopropyl-4β-methyl-9β-hydroxy spiro[4.5]dec-6-en-8-one (2), one new natural product, 4-hydroxy-4, 6-dimethyl-1-tetralone (3), and one known acorane sesquiterpene, acoradiepoxide (4) were isolated from the twigs and leaves of Illicium henryi. The structures of the new compounds were elucidated primarily on the basis of analysis of spectroscopic data. In addition, the inhibitory effect on NO production of these compounds were tested. Compounds 1 and 4 exhibited slight inhibitory e...

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