Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients

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成果类型：

期刊论文

作者：

Liu, Yong;Tao, Huai;Yang, Xiudeng;Huang, Kai;Zhang, Xianghui;...

通讯作者：

Li, Cunyan

作者机构：

[Zhang, Xianghui; Liu, Yong; Huang, Kai] Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.

[Zhang, Xianghui; Liu, Yong; Huang, Kai] China Natl Clin Res Ctr Mental Disorders Xiangya, Changsha, Hunan, Peoples R China.

[Zhang, Xianghui; Liu, Yong; Huang, Kai] China Natl Technol Inst Mental Disorders, Changsha, Hunan, Peoples R China.

[Zhang, Xianghui; Liu, Yong; Huang, Kai] Cent S Univ, Mental Hlth Inst, Changsha, Hunan, Peoples R China.

[Zhang, Xianghui; Liu, Yong; Huang, Kai] Hunan Key Lab Psychiat & Mental Hlth, Changsha, Hunan, Peoples R China.

通讯机构：

[Li, Cunyan] H

Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Dept Lab Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

FES;Hcy;IL-6;OXT;OXTR;hsCRP

期刊：

Frontiers in Psychiatry

ISSN：

1664-0640

年：

2019

卷：

期：

APR

页码：

217

DOI：

10.3389/fpsyt.2019.00217

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81771448]; Hunan Provincial Science and Technology Bureau Foundation of China [2017SK50509]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JJ4069, 2018JJ2580, 2018JJ3387]

机构署名：

本校为其他机构

院系归属：

医学院

中医学院

摘要：

Schizophrenia (SZ) is a debilitating and heterogeneous disease. We hypothesized that the oxytocin (OXT) system, inflammation and one-carbon metabolism would have a link with SZ. In this study, serum OXT, OXT receptor (OXTR), interleukin-6 (IL-6), high sensitivity CRP (hsCRP) and homocysteine (Hcy) levels were measured in 52 first-episode schizophrenia (FES) patients and 41 healthy controls (HC) from the Second Xiangya Hospital of Central South University. Meanwhile, the mRNA expressions of OXT and OXTR genes were determined by real-time quantitative PCR. Serum OXT and OXTR levels were signific...

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Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients

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