期刊论文

Liu, Wei;Dai, AG

英文

In Vitro Cellular & Developmental Biology - Animal

1071-2690

2025

61

1

107-116

10.1007/s11626-024-00976-2

This work was financially supported by the Scientific Research Project of Health Commission of Hunan Province (project number, 202203022565), Natural Science Foundation of Hunan Province (project number, 2022JJ40221), and Hunan Natural Science Foundation (project number, 2023JJ60304).

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Pulmonary hypertension (PH) is a condition in which the smooth muscle cells (SMCs) in the pulmonary arteries multiply excessively, causing the arteries to narrow. This can ultimately result in right heart failure and premature death. Notch3 is an important factor involved in pulmonary vascular remodeling in PH. RO4929097, as a gamma-secretase inhibitor that inhibits Notch3 signaling pathway, may be a potential drug for the treatment of PH, but its feasibility and related mechanism of action need to be further investigated. In vitro modeling by hypoxic incubation of human pulmonary artery SMCs ...