期刊论文

中文

中国老年学杂志

1005-9202

2014

34

7

1873-1875

10.3969/j.issn.1005-9202.2014.07.066

湖南中医药管理局项目(2009033) 湖南中医药管理局重点项目(201232) 湖南大学生研究生学习和创新性实验计划项目(2013679)

本校为第一机构

目的研究冠盖藤对骨性关节炎(OA)大鼠血常规及血清中白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)、IL-6水平的影响。方法采用弗氏完全佐剂制备OA模型,将随机造模成功后大鼠随机分为模型组,雷公藤组,冠盖藤高、中、低剂量组。经药物干预28 d后,检测血常规及血清细胞因子水平。结果与正常组比较,模型组的血常规中白细胞、中性粒细胞数明显升高,血清IL-1β、IL-6、TNF-α的水平出现升高,经冠盖藤干预后血常规中白细胞、中性粒细胞数明显下降,血清中IL-1β、IL-6、TNF-α的水平明显降低,并且以高剂量组最明显。结论冠盖藤的抗炎镇痛机制之一可能通过降低白细胞、中性粒细胞数,血清IL-1β、IL-6、...

Objective To study effect of Pileostegia viburnoides Hook.f.et Thorns on blood count and levels of serum interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) in osteoarthritis rat.Methods Osteoarthritis model was made by Freund's Complete Adjuvant(FCA),then osteoarthritis model rats were randomly divided into model,tripterygium,high-,middle-,low-dose of Pileostegia viburnoides Hook.f.et Thorns.Rats were detected blood and serum cytokine levels after intervention 28 days later.Results Compared with the normal group,blood ...