\\Ameliorative effect of Luffa cylindrica fruits on Caenorhabditis elegans and cellular models of Alzheimer\'s disease-related pathology via autophagy induction - 成果

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\Ameliorative effect of Luffa cylindrica fruits on Caenorhabditis elegans and cellular models of Alzheimer's disease-related pathology via autophagy induction

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Long, Tao;Chen, Xue;Qin, Da-Lian;Zhu, Yun-Fei;Zhou, Yu-Jia;...

通讯作者：

Wu, Jian-Ming;Wu, An-Guo;Zhou, XG

作者机构：

[Zhou, Yu-Jia; Fu, Hai-Jun; Tang, Yong; Zhou, Xiao-Gang; Law, Betty Yuen-Kwan; Huang, Fei-Hong; Wu, Jian-Ming; Long, Tao; Chen, Xue; Wang, Long; Yu, Chong-Lin; Qin, Da-Lian; Wu, An-Guo; He, Yan-Ni; Yu, Lu; Zhu, Yun-Fei] Southwest Med Univ, Sch Pharm, Sichuan Key Med Lab New Drug Discovery & Drugabil, Luzhou Key Lab Act Screening & Drugabil Evaluat Ch, Luzhou, Sichuan, Peoples R China.

[Fu, Hai-Jun; Zhou, Xiao-Gang; Long, Tao; Chen, Xue; He, Yan-Ni; Zhu, Yun-Fei] Cent Nervous Syst Drug Key Lab Sichuan Prov, Luzhou, Sichuan, Peoples R China.

[Zhou, Yu-Jia] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Hunan, Peoples R China.

[Law, Betty Yuen-Kwan] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.

[Wu, Jian-Ming; Zhou, Xiao-Gang; Wu, JM; Wu, An-Guo; Zhou, XG] Southwest Med Univ, Sch Pharm, Sichuan Key Med Lab New Drug Discovery & Drugabil, Luzhou Key Lab Act Screening & Drugabil Evaluat Ch, Luzhou 646000, Sichuan, Peoples R China.

通讯机构：

[Wu, AG; Zhou, XG ; Wu, JM] S

Southwest Med Univ, Sch Pharm, Sichuan Key Med Lab New Drug Discovery & Drugabil, Luzhou Key Lab Act Screening & Drugabil Evaluat Ch, Luzhou 646000, Sichuan, Peoples R China.

语种：

英文

关键词：

Alzheimer's disease;Aβ;Luffa cylindrica;autophagy;medicine food homology;tau

期刊：

Phytotherapy Research

ISSN：

0951-418X

年：

2023

卷：

期：

页码：

4639-4654

DOI：

10.1002/ptr.7931

基金类别：

National Natural Science Foundation of China [81801398, 81903829]; Science and Technology Planning Project of Sichuan Province, China; Joint Project of Luzhou Municipal People's Government and Southwest Medical University, China; project of Southwest Medical University, China [2022YFS0620, 2020YJ0494, 2021YJ0180, 2020LZXNYDJ37, 20YKDYYJC0067]; Macao Science and Technology Development Fund of Macao SAR; [2021ZKZD015]; [2020ZRZD015]; [2021ZKMS046]; [2021ZKZD018]; [2019ZQN174]; [MUST-SKL-2021-00]; [SKL-QRCM (MUST)-2020-2022]

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

BACKGROUND: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder without an effective cure. Natural products, while showing promise as potential therapeutics for AD, remain underexplored. AIMS: This study was conducted with the goal of identifying potential anti-AD candidates from natural sources using Caenorhabditis elegans (C. elegans) AD-like models and exploring their mechanisms of action. MATERIALS & METHODS: Our laboratory's in-house herbal extract library was utilized to screen for potential anti-AD candidates using the C. ...

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