MiRNA320a Inhibitor-Loaded PLGA-PLL-PEG Nanoparticles Contribute to Bone Regeneration in Trauma-Induced Osteonecrosis Model of the Femoral Head

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成果类型：

期刊论文

作者：

Zhang, Ying*;Li, Chuan;Wei, Qiushi;Yuan, Qiang;He, Wei;...

通讯作者：

Zhang, Ying;Cao, XY

作者机构：

[Zhang, Leilei; Cao, XY; Zhang, Ying; Cao, Xiangyang] Luoyang Orthoped Traumatol Hosp, Orthoped Hosp Henan Prov, Med Ctr Hip, 82 Qiming South Rd, Luoyang 471002, Henan, Peoples R China.

[Li, Chuan] 920Th Hosp Joint Logist Support Force, Dept Oncol, Kunming 650032, Yunnan, Peoples R China.

[Wei, Qiushi; He, Wei] Guangzhou Univ Tradit Chinese Med, Inst Orthopaed, Guangzhou 510240, Peoples R China.

[Wei, Qiushi; He, Wei] Guangzhou Univ Tradit Chinese Med, Affiliated Hosp 3, Guangzhou 510240, Peoples R China.

[Jing, Zhenhao; Yuan, Qiang; Dong, Yiping] Henan Univ Tradit Chinese Med, Zhengzhou 450046, Henan, Peoples R China.

通讯机构：

[Cao, XY ; Zhang, Y] L

Luoyang Orthoped Traumatol Hosp, Orthoped Hosp Henan Prov, Med Ctr Hip, 82 Qiming South Rd, Luoyang 471002, Henan, Peoples R China.

语种：

英文

关键词：

Osteonecrosis of the femoral head;Sustained release system;PEG-PLGA-PLL nanoparticle;MiR-320a;Bone regeneration

期刊：

TISSUE ENGINEERING AND REGENERATIVE MEDICINE

ISSN：

1738-2696

年：

2024

卷：

期：

页码：

185-197

DOI：

10.1007/s13770-023-00580-7

基金类别：

This work was supported by National Science Foundation of China (Grant Number 81774348 and 81874477); and Science and Technology Project of Henan Province (Grant number 212102310365). [81774348, 81874477]; National Science Foundation of China [212102310365]; Science and Technology Project of Henan Province

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摘要：

BACKGROUND: This study aimed to explore the effect of a nanomaterial-based miR-320a inhibitor sustained release system in trauma-induced osteonecrosis of the femoral head (TIONFH). METHODS: The miR-320a inhibitor-loaded polyethylene glycol (PEG)- Poly(lactic-co-glycolic acid) (PLGA)- Poly-L-lysine (PLL) nanoparticles were constructed using the double emulsion method. The TIONFH rabbit model was established to observe the effects of miR-320a inhibitor nanoparticles in vivo. Hematoxylin-eosin staining and microcomputed tomography scanning were us...

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MiRNA320a Inhibitor-Loaded PLGA-PLL-PEG Nanoparticles Contribute to Bone Regeneration in Trauma-Induced Osteonecrosis Model of the Femoral Head

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