Polyphyllin I induced ferroptosis to suppress the progression of hepatocellular carcinoma through activation of the mitochondrial dysfunction via Nrf2/HO-1/GPX4 axis

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成果类型：

期刊论文

作者：

Yang, Renyi;Gao, Wenhui;Wang, Zhibing;Jian, Huiying;Peng, Lian;...

通讯作者：

Peng, Wei;Li, Kexiong;Zeng, PH

作者机构：

[Yang, Renyi; Zeng, Puhua; Jian, Huiying; Xue, Peisen; Li, Kexiong; Li, KX; Yu, Xiaopeng; Peng, Wei; Peng, W] Hunan Acad Chinese Med, Hunan Prov Hosp Integrated Tradit Chinese & Wester, Canc Res Inst, Hunan Acad Tradit Chinese Med, Changsha 410006, Hunan, Peoples R China.

[Gao, Wenhui; Peng, Lian] Hunan Univ Chinese Med, Sch Tradit Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Wang, Zhibing] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Li, KX; Zeng, PH ; Peng, W] H

Hunan Acad Chinese Med, Hunan Prov Hosp Integrated Tradit Chinese & Wester, Canc Res Inst, Hunan Acad Tradit Chinese Med, Changsha 410006, Hunan, Peoples R China.

语种：

英文

关键词：

Ferroptosis;Hepatocellular carcinoma;Mitochondrial dysfunction;Nrf2/HO-1/GPX4 axis;Polyphyllin I

期刊：

Phytomedicine

ISSN：

0944-7113

年：

2024

卷：

122

页码：

155135

DOI：

10.1016/j.phymed.2023.155135

机构署名：

本校为第一且通讯机构

院系归属：

中西医结合学院

摘要：

BACKGROUND: Ferroptosis is an emerging iron-dependent programmed cell death mode characterized by lipid peroxidation and iron accumulation, closely associated with Hepatocellular Carcinoma (HCC) progression. Although the impact of Polyphyllin I (PPI), a prominent bioactive constituent derived from Paris polyphylla, on diverse malignancies has been established, the specific role and potential mechanistic pathways through which PPI modulates ferroptosis in HCC remain elusive. PURPOSE: This study aimed to elucidate the anti-cancer properties and potential mechanisms of PPI in inducing ferroptosis...

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Polyphyllin I induced ferroptosis to suppress the progression of hepatocellular carcinoma through activation of the mitochondrial dysfunction via Nrf2/HO-1/GPX4 axis

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