期刊论文

Preliminary Exploration of Orientation and Method of Chromatographic Pharmacodynamics of Traditional Chinese medicine

中文

世界科学技术-中医药现代化

1674-3849

2004

6

6

44-50

10.3969/j.issn.1674-3849.2004.06.011

国家中医药管理局中医药科研基金（02-03ZP4）资助的“总量统计矩原理对补阳还五汤有效部位药物动力学研究”课题的子课题；

本校为第一机构

目的:提出中药谱效学基本概念、研究方向及方法.方法:根据目前中医药学科的现代科学属性,结合相关交叉学科知识与文献,以及近几年科研工作,对其方法进行初探.结果:提出了首先应建立与动物(人)"证"模型相对应的状态函数关系式的现代中医药数理表述体系,再根据与"证"相一致所对应的基因表达下特性蛋白质与效应体(药物)的齿合关系,按亲合色谱,以效应体靶向分离物--特性蛋白质为固定相,采用LC/MS质量或效应型检测器,建立质量或效应指纹图谱.根据效应体作用前后(体内药物浓度为零)效应值的变化趋势研究该指纹图谱与生物体状态函数值变化关系,可揭示中药复方作用物质基础:包括效应体(结合成分群)的数目...

Objective: To propose the basic concepts and the study orientation and method of the chromatographic pharmaco-dynamics of traditional Chinese medicine (TCM). Method: To preliminarily explore its study method in accordance with the modern characters of TCM disciplines and in combination of the knowledge and literature of relevant cross - disciplines as well as the research results made in recent years. Result: It is proposed that a system of TCM mathematic expression of state function relationship, which corresponds to the ' syndromes' of animal ( human being ) models and then a fingerprint of ...