期刊论文

Investigation on Chromatogram-pharmacodynamics Relationship of Three Kinds of Xiao-Yao Formula on the Effect of Shu-Gan-Jie-Yu

中文

世界科学技术-中医药现代化

1674-3849

2012

5

2021-2028

10.3969/j.issn.1674-3849.2012.05.015

湖南省长沙市科技局重点课题（K0802103-31）：名方逍遥方抗抑郁有效组分新制剂的研制,负责人：蔡光先.

本校为第一机构

目的:确定逍遥方3种制剂指纹图谱特征峰所代表的化学成分与疏肝解郁功效的关系,为建立“指纹图谱与药效关联”的中药质量控制模式提供理论依据和数据支持.方法:HPLC法研究逍遥方3种不同制剂的化学成分,即传统丸剂、汤剂、新制剂,采用复合病因肝郁脾虚模型探究其药理效应,灰关联度分析法解析逍遥方3种制剂的谱效关系.结果:逍遥方3种制剂疏肝解郁的功效是其所有化学成分共同作用的结果,按照关联度的大小排列逍遥方不同制剂指纹图谱对疏肝解郁作用相关的成分峰来源,依次为新制剂峰>汤剂峰>丸剂峰.结论:新制剂所用工艺合理、质量稳定,该评价方法对经典名方的研究与开发具有重要的价值.

This study was aimed to investigate the relationship between HPLC fingerprint of three kinds of agents and the effect of Shu-Gan-Jie-Yu, and to provide both theory and data basis for an innovative approach of quality control of traditional Chinese medicine （TCM）. HPLC was introduced to analyze fingerprint of three kinds of agents, namely the traditional pill, herbal decoction and new formulation. Complex etiology model was used to study the pharmacological effects. Correlation between fingerprint and effect of Shu-Gan-Jie-Yu were identified u...