期刊论文

Effects of Different Routes of Medication of Grub Extract onWet Age-related Macular Degeneration

中文

世界科学技术-中医药现代化

1674-3849

2018

20

1

109-117

10.11842/wst.2018.01.019

湖南省中医药科研重点项目（201438）：湖南省研究生创新课题（CX2014B352） 湖南省***卫生人才“225”工程培养项目资助 国家中医药管理局中医眼科学重点学科建设项目

本校为第一机构

目的:研究蛴螬提取物不同途径给药对对激光诱导鼠眼CNV模型的影响及作用机制.方法:将BN大鼠32只随机分成空白组、模型组、口服组、滴眼组.采用激光诱导建立CNV活体模型,口服组、滴眼组分别予以蛴螬提取物口服和滴眼干预.分别在用药后1W、2W、3W、4W行眼底照相、FFA、OCT检查,观察CNV的形成情况,在2W、4W时对视网膜Ang1、HTRA1、VEGF进行检测.结果:两种给药方式均能有效减轻眼底视网膜血管荧光渗漏,促进瘢痕形成,稳定视网膜各层正常的结构及功能,减少激光对视网膜外屏障的损伤,减少新生血管形成,促进有效侧支循环的建立.新生血管形成率比较有统计学差异(P0.05),HTRA1、VEGF仍维持高表达.模型组与...

This paper was aimed to study the mechanism of different routes of medication of grub extract on wet agerelated macular degeneration (AMD). A total of 32 BN rats were randomly divided into four groups, which included the healthy control group (A group), model group (B group), oral administration group (C group), and eye drops group (D group). B, C, D group were made the wet AMD model induced in laser. C, D group were given grubs extract oral administration and eye drops, respectively. After 1 week, 2 weeks, 3 weeks and 4 weeks, fundus photography, FFA and OCT were conducted. The production of ...