期刊论文

A Network Pharmacology Approach to Explore the Molecular Mechanism of Taoren-Honghua Pair on Syndrome of Blood Stasis

中文

世界科学技术-中医药现代化

1674-3849

2018

20

12

2208-2216

10.11842/wst.2018.12.019

国家自然科学基金委面上基金项目(81774174):基于细胞铁转运网络调控机制探讨缺血性中风气虚血瘀证的生物学基础,负责人:葛金文.

本校为第一机构

目的:采用网络药理学方法探讨桃仁-红花药对活血化瘀作用的药理学分子机制。方法:在中医药数据库收集筛选桃仁-红花药对化学成分信息的基础上,分别应用Scifinder和Pharm Mapper搜集和预测化学成分的已知靶点与潜在靶点应用DAVID数据库进行KEGG通路注释分析。根据桃仁-红花药对的已知靶点搜集、潜在靶点预测以及富集分析的结果运用Cytoscape构建成分-预测靶点网络模型和成分-靶点-通路网络模型,并分析其作用机制。结果:桃仁-红花药对的17个化学成分返回了74个已知靶点,其已知靶点与改善血流动力学、抗凝血、抗炎、调控细胞凋亡和增殖四个模块有关。并通过Pharm Mapper接获得317个预测靶点和通过通...

Objective: To explore the molecular mechanism of Taoren-Honghua herb pair (THP) on syndrome of blood stasis based on the network pharmacology. Methods: We collected THP’s compounds from traditional Chinese Medicine databases and input them into Pharm Mapper to get their potential targets, and collected the known targets of compounds by Scifinder. Then we did KEGG- pathway analysis by DAVID database. Finally draw and analyze the network by Cytoscape by information above. Results: Seventeen compounds of THP acquired 74 known targets, which was a...