期刊论文

Current Research on Mechanism of Ferroptosis

中文

世界科学技术-中医药现代化

1674-3849

2019

21

10

2151-2158

10.11842/wst.20181101001

国家自然科学基金委员会面上项目（81774033）：脑缺血后胶质细胞铁代谢与炎症损伤机制研究及脑泰方干预作用，负责人：廖君;国家自然科学基金委员会面上项目（81774174）：基于细胞铁转运网络调控机制探讨缺血性中风气虚血瘀证的生物学基础，负责人：葛金文； 湖南省教育厅优秀博士学位论文获得者项目（YB2016B030）：基于HIF-1a/VEGF通路调节DMT1表达探讨脑泰方抗脑缺血损伤分子机制研究，负责人：廖君；

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铁死亡概念是Dixon等在Cell杂志上首次提出,定义为铁依赖的,脂质过氧化物生成所致的一种新型细胞死亡方式。铁死亡是神经系统疾病如AD、PD等的损伤机制,癌症发病过程中出现铁离子聚集,诱导铁死亡是癌症治疗的新型靶点。本文系统介绍铁死亡机制及与疾病治疗的研究进展,为疾病发生机制研究和临床药物靶点提供新思路。

The concept of iron death was first proposed in Cell magazine. It was defined as a novel cell death pattern caused by iron peroxide-dependent lipid peroxide formation. Iron death is the damage mechanism of some nervous system diseases such as AD and PD. Iron ions accumulate in the process of cancer development, and leading to ferroptosis is a new target of cancer treatment. In this paper, the mechanism of ferroptosis and the research progress of the diseases are introduced systematically, which provide new ideas for the res...