期刊论文

Inhibitory Effect of Moxibustion on Tumor Growth in Rats with Gastric Tumor Bearing

中文

世界科学技术-中医药现代化

1674-3849

2019

21

9

1994-2000

10.11842/wst.20181023008

国家自然科学基金委员会面上项目（81574077）：艾灸诱导HSP-PCs产生并回输体内对荷瘤大鼠肿瘤细胞抑制效应的研究，负责人：林亚平； 湖南省教育厅优秀青年项目（18B257）：从促炎因子→NF-κB→UPS途径，探讨艾灸对胃癌恶病质大鼠骨骼肌消耗的治疗作用与机理，负责人：谭静；

本校为第一机构

目的观察艾灸对胃荷瘤大鼠瘤体增长的抑制作用。方法 50只健康SD大鼠,随机分为空白组、假手术组、模型组、艾灸组、红外组5组,每组10只。采用Walker-256细胞实体瘤组织移植胃部制备动物模型。成模后,艾灸组、红外组分别施以温和灸、红外线治疗20 min,每日1次,持续21 d。实验期间,观察大鼠的生存状态,记录饮食、体重等变化。治疗结束后,摘取胃部,测量肿瘤体积、计算生长抑制率。采用免疫组化法,观测肿瘤细胞增殖细胞核抗原（Proliferating Cell Nuclear Antigen, PCNA）的表达,TUNEL观测肿瘤细胞凋亡。结果实验期间,模型组动物生存状态持续变差,成模5 d后生存状态积分明显低于空白组（P

Objective To observe the inhibitory effect of moxibustion on tumor growth in gastric tumor bearing rats.Methods Fifty healthy SD rats were randomly divided into 5 groups:blank group,sham operation group,model group,moxibustion group and infrared group,with 10 rats in each group.Walker-256 cell solid tumor tissue was transplanted into the stomach to prepare animal models.After modeling,moxibustion group and infrared group were treated with mild moxibustion and infrared ray for 20 minutes,once a day for 21 days.During the experiment,the survival state of rats was observed and recorded.After trea...