期刊论文

Exploration on the Potential Molecular Mechanism of Zhuifeng Tougu Capsules in Treating Different Diseases Such as Rheumatoid Arthritis and Osteoarthritis with the Same Method Based on Network Pharmacology and Molecular Docking Technology

中文

世界科学技术-中医药现代化

1674-3849

2020

22

10

3526-3537

10.11842/wst.20200424008

国家科学技术部重点研发计划项目（2018YFC2002500）：老年病中医早期识别、干预及综合服务技术的示范研究，负责人：张荣华； 湖南中医药大学第一附属医院中央补助项目（rsk-011-14）：第六批名老中医药专家学术经验继承指导，负责人：卢敏； 湖南省科学技术厅自然科学基金项目（2019JJ50462）：从肠道菌群介导的TLR4-MyD88通路研究追风透骨胶囊治疗膝骨关节炎的效应机制，负责人：邝高艳；

本校为第一机构

目的 利用网络药理学方法及分子对接的方法预测追风透骨胶囊治疗类风湿关节炎(rheumatoid arthritis,RA)及骨关节炎(osteoarthritis,OA)的活性成分、作用靶点及相关生物学途径,丰富其异病同治的科学内涵.方法 利用TCMSP、BATMAN-TCM数据库筛选出追风透骨胶囊的活性成分及治疗RA及OA的对应靶点,采用Cytoscape 3.7.0软件构建"药物-化合物-共有靶标"网络图,运用STRING平台构建靶蛋白相互作用(protein-protein interaction,PPI)网络,运用R语言数据包进行基因本体功能富集(gene ontology,GO)与京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomics,KEGG)富集分析,预测其作用机制,最后...

Objective To predict active components,action targets and relevant biological processes of Zhuifeng Tougu Capsules in treatment of rheumatoid arthritis (RA) and osteoarthritis (OA) by means of network pharmacology and molecular docking,and to enrich its scientific connotation of treating different diseases with the same method.Methods TCMSP,BATMAN-TCM databases were applied to screen the active components of Zhuifeng Tougu Capsules and the corresponding targets in the treatment for RA and OA.Cytoscape 3.7.0 software was used to construct a netw...