期刊论文

中文

世界科学技术-中医药现代化

1674-3849

2022

24

2

694-704

10.11842/wst.20210928017

湖南省中医药管理局湖南省中医药科研计划重点项目（2020021）：基于P38MAPK、AKT信号通路研究治伤巴布剂干预急性软组织损伤分子机制，负责人：李前； 常德市科学技术局一般项目（2019S212）：基于P38MAPK信号通路研究治伤巴布剂干预急性软组织损伤分子机制，负责人：邵先舫；

本校为第一机构

目的 观察治伤巴布剂对急性软组织损伤(acute soft tissue injury,ASTI)模型p38丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)、丝/苏氨酸蛋白激酶(AKT)信号通路的影响,探讨治伤巴布剂干预ASTI的可能作用机制.方法 将40只雄性SD大鼠按照随机数字表法分为正常对照组、模型对照组、治伤巴布剂组、p38MAPK信号通路抑制剂组、AKT信号通路抑制剂组,每组8只.除正常对照组外,其余四组均予以左侧后肢小腿ASTI造模.造模成功后,治伤巴布剂组于标记部位立即予治伤巴布剂(修剪成1.5×3cm大小)外敷,并用胶布固定;其余四组均予等剂量赋形剂(修剪成1.5×3 cm大小)外敷处理,胶布固定;持续外敷,共持...

Objective To observe the effects of injury-curing cataplasm on p38MAPK and AKT signaling pathways in acute soft tissue injury model, and to explore the possible mechanism of injury treatment babu agent on ASTI.Methods Forty male SD rats were divided into normal control group, model control group, injury-curing cataplasm group,p38MAPK signaling pathway inhibitor group and AKT signaling pathway inhibitor group according to random number table method, with 8 rats in each group. Except for the normal control group, the other four groups underwent A...