OBJECTIVE: To observe the curative effect of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser pulse in treating dentine hypersensitivity. METHOD: A total of 262 teeth with dentine hypersensitivity were divided equally into 2 groups, namely the test group which received treatment with pulse Nd: YAG laser and the control group treated with sodium fluoride. RESULTS: The instant, 1-month and 6-month effectiveness in the test group was better than that in the control group, showing significant difference between the two groups (P