Correlation Analysis of C-terminal telopeptide of collagen type II and Interleukin-1β for Early Diagnosis of Knee Osteoarthritis

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成果类型：

期刊论文

作者：

Liu, Cai-xia;Gao, Ge;Qin, Xiao-qun;Deng, Chang-qing;Shen, Xiong-jie

通讯作者：

Shen, XJ

作者机构：

[Liu, Cai-xia; Deng, Chang-qing] Hunan Univ Tradit Chinese Med, Sch Integrated Chinese & Western Med, Changsha, Hunan, Peoples R China.

[Gao, Ge] Cent South Univ, Xiangya Hosp 3, Fac Lab Med, Changsha, Hunan, Peoples R China.

[Qin, Xiao-qun] Cent South Univ, Xiangya Sch Med, Dept Physiol, Changsha, Hunan, Peoples R China.

[Shen, Xiong-jie] Hunan Prov Peoples Hosp, Dept Spine Surg, Changsha 410005, Hunan, Peoples R China.

通讯机构：

[Shen, XJ ] H

Hunan Prov Peoples Hosp, Dept Spine Surg, Changsha 410005, Hunan, Peoples R China.

语种：

英文

关键词：

calcium sulfate;carboxy terminal telopeptide;collagen type 2;interleukin 1beta;sodium chloride;biological marker;C-terminal cross-linking telopeptide of type II collagen, human;collagen type 2;IL1B protein, human;interleukin 1beta;peptide fragment;adult;age;american college of rheumatology criteria;animal experiment;animal model;animal tissue;Article;assessment of humans;body mass;clinical article;controlled study;correlation analysis;diagnostic value;early diagnosis;enzyme linked immunosorbent assay;experimental osteoarthritis;female;human;human tissue;kellgren lawrence score;knee osteoarthritis;male;middle aged;New Zealand White (rabbit);nonhuman;protein urine level;rabbit model;scoring system;tissue section;aged;animal;blood;knee osteoarthritis;Leporidae;metabolism;urine;Aged;Animals;Biomarkers;Collagen Type II;Female;Humans;Interleukin-1beta;Male;Middle Aged;Osteoarthritis, Knee;Peptide Fragments;Rabbits

期刊：

Orthopaedic Surgery

ISSN：

1757-7853

年：

2020

卷：

期：

页码：

286-294

DOI：

10.1111/os.12586

基金类别：

This work was supported by the Hunan Natural Science Foundation [2016JJ4053], Renshu development fund of Hunan Provincial People's Hospital [201305] and the Basic Medicine (First‐Class Discipline) Construction Project of the “13th 5‐year plan” from Hunan University of Traditional Chinese Medicine [06].

机构署名：

本校为第一机构

院系归属：

中西医结合学院

摘要：

Objective: To analyze the correlation between the Kellgren–Lawrence (K-L) score of knee osteoarthritis (KOA) patients with different degrees and their urine concentration of C-terminal telopeptide of collagen type II (CTX-II) and interleukin-1β (IL-1β), and to further evaluate the diagnostic value of CTX-II and IL-1β during the pathological process by producing an experimental osteoarthritis (OA) model in rabbits. Methods: From 1 January 2017 to 31 December 2018, a total of 34 subjects (7 mild, 9 moderate, 9 severe arthritis patients, and 9...

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Correlation Analysis of C-terminal telopeptide of collagen type II and Interleukin-1β for Early Diagnosis of Knee Osteoarthritis

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