Apigenin inhibits angiogenesis in retinal microvascular endothelial cells through regulating of the miR-140-5p/HDAC3-mediated PTEN/PI3K/AKT pathway

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Fu, Chaojun;Peng, Jun;Ling, Yanjun;Zhao, Hongqing;Zhao, Yongwang;...

通讯作者：

Peng, Qinghua;Qin, YH

作者机构：

[Peng, Qinghua; Zhao, Hongqing; Zhang, Xiuli; Qin, Yuhui; Fu, Chaojun; Ai, Min] Hunan Univ Chinese Med, Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Hanpu Rd, Changsha 410208, Hunan, Peoples R China.

[Peng, Qinghua; Qin, Yuhui; Fu, Chaojun; Ai, Min] Hunan Engn Technol Res Ctr Prevent & Treatment Oto, Changsha 410208, Hunan, Peoples R China.

[Peng, Jun] Hunan Univ Chinese Med, Hosp 1, Ophthalmol Dept, Shaoshan Rd, Changsha 410007, Hunan, Peoples R China.

[Ling, Yanjun] Inst Chinese Med Hunan Prov, Lushan Rd, Changsha 410006, Hunan, Peoples R China.

[Zhao, Yongwang] Shanghai Jiao Tong Univ, Peoples Hosp 1, Ophthalmol Dept, Songjiang Branch, Zhongshan Zhong Rd, Shanghai 201699, Peoples R China.

通讯机构：

[Peng, QH; Qin, YH ] H

Hunan Univ Chinese Med, Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Hanpu Rd, Changsha 410208, Hunan, Peoples R China.

Hunan Engn Technol Res Ctr Prevent & Treatment Oto, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Apigenin;miR-140-5p/HDAC3;PTEN/PI3K/AKT;Angiogenesis;Diabetic retinopathy

期刊：

BMC Ophthalmology

ISSN：

1471-2415

年：

2023

卷：

期：

页码：

1-11

DOI：

10.1186/s12886-023-03046-5

基金类别：

This work was supported by the Natural Science Foundation of China (No. 81874493), the Natural Science Foundation of Hunan Province (No. 2020JJ5413, No. 2020SK2123), the Excellent Youth Foundation of Hunan Educational Committee (No. 19B431, No. 19B426), 2022 Hunan University of Chinese Medicine First-class Discipline Open Fund Project (No. 2022ZYX04).

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

Diabetic retinopathy (DR) is a common cause of visual impairment. Apigenin has been shown to have antiangiogenic effects in various diseases. Our study aimed to investigate the role of apigenin in DR and elucidate the underlying mechanism. Human retinal microvascular endothelial cells (HRMECs) were exposed to high glucose (HG) to establish a DR model. HRMECs were treated with apigenin. Then we knocked down or overexpressed miR-140-5p and HDAC3, and added PI3K/AKT inhibitor LY294002. The expression levels of miR-140-5p, HDAC3, and PTEN were measured using qRT-PCR. Western blot analysis was perf...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Apigenin inhibits angiogenesis in retinal microvascular endothelial cells through regulating of the miR-140-5p/HDAC3-mediated PTEN/PI3K/AKT pathway

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问