Bioinformatic Analysis and in Vitro Experimental Verification of the Intervention Effect of Shipi-Xiaoji Recipe on the Progression of non-Alcoholic Fatty Liver Disease to Liver Cancer
Key Project of Hunan Provincial Administration of Traditional Chinese Medicine#&#&#A2023042
the Innovation Project for postgraduate students at Hunan University of Chinese Medicine#&#ߧCX26
Hunan Provincial Health Commission Traditional Chinese Medicine Shennong Leading Talent Project
Young Qihuang Scholars Talent Project of National Administration of Traditional Chinese Medicine
Natural Science Foundation of Hunan Province#&#ߧJJ30364#&#ߧJJ40400
Hunan Provincial Traditional Chinese Medicine Research Program#&#&#D2022010
National Natural Science Foundation of China#&#�
Hunan Province Science and Technology Top Leading Talent Project
机构署名：
本校为第一且通讯机构
摘要：
Objective This study aimed to screen and identify central genes associated with the progression of non-alcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC), to establish prognostic and clinical prediction models based on the expression of these genes, and to evaluate the intervention of a traditional Chinese medicine (TCM) formula—SPXJF—on the development of NAFLD into HCC through network pharmacology analysis and in vitro and in vivo validation. Methods Datasets for analysis were retrieved from multiple public databases us...
