期刊论文

Pulmonary protection of Xuebijing injection on lung injury induced by cardiac pulmonary bypass

中文

中国急救医学

1002-1949

2017

37

4

322-325

10.3969/j.issn.1002-1949.2017.04.009

湖南省中医药科研计划项目（201696） 中医内科学省部共建教育部重点实验室开放基金资助项目（ZYNK201506）

本校为第一机构

目的探讨血必净注射液(XBJ)对体外循环(CPB)所致急性肺损伤的保护作用及可能的机制。方法50例风湿性心脏病需行二尖瓣置换术的患者随机分为实验组(XBJ组)和对照组(C组),每组25例。XBJ组在切皮后CPB前静脉输注血必净注射液100 mL,对照组静脉输注相同剂量生理盐水。分别于CPB前(T_0)、主动脉开放30 min(T_1)、术毕(T_2)、术后6 h(T_3)、术后24 h(T_4)测定患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL - 6)及超氧化物歧化酶(SOD),同时记录呼吸参数并行动脉血气分析计算各时间点的呼吸指数(RI)和氧合指数(01)。结果CPB前两组患者血清TNF-α、IL-6、SOD及呼吸参数比较差异无统计学意义(P均>0.0...

Objective To investigate the pulmonary protection of Xuebijing injection in patients undergoing open heart surgery. Methods Fifty patients with rheumatic heart disease undergoing mitral valve replacement were randomly divided into two groups: experimental group (XBJ group n = 25) received 100 mL Xuebijing injection intravenously for before CPB and equal volume normal saline was used instead of XBJ in control group (C group n = 25). Interleukin (IL - 6),TNF - α and SOD were respectively measured at five different time intervals including before...