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The identification of sex-specific biomarkers in peripheral blood mononuclear cells from elderly individuals with ischemic stroke

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成果类型:
期刊论文
作者:
Qin, L. -H.;Chen, L.;Cao, X.;Huang, T. -J.;Li, Z. -Y.;...
通讯作者:
Qin, LH
作者机构:
[Li, Z. -Y.; Cao, X.; Qin, LH; Chen, L.; Qin, L. -H.; Huang, T. -J.] Hunan Univ Chinese Med, Sch Nursing, Changsha, Peoples R China.
[Li, S.; Qin, LH; Qin, L. -H.] Hunan Univ Chinese Med, Key Lab Hunan Prov Prevent & Treatment Integrated, Changsha, Peoples R China.
[Wang, G. -Z.] Hunan Univ Chinese Med, Clin Sch Chinese Med 2, Changsha, Peoples R China.
通讯机构:
[Qin, LH ] H
Hunan Univ Chinese Med, Sch Nursing, Changsha, Peoples R China.
Hunan Univ Chinese Med, Key Lab Hunan Prov Prevent & Treatment Integrated, Changsha, Peoples R China.
语种:
英文
关键词:
Ischemic stroke;Differentially expressed genes;Sex-specific;Elderly
期刊:
European Review for Medical and Pharmacological Sciences
ISSN:
1128-3602
年:
2023
卷:
27
期:
14
页码:
6496-+
基金类别:
National Natural Science Foundation of China [81904180]; Scientific Research Project of Hunan Provincial Health Commission [B202319018677]; Scientific Research Fund of Hunan Provincial Education Department [22A0266, 20B429]; Hunan Provincial Natural Science Foundation of China [2023JJ50035]; 2022 "Disciplinary Reveal System" project of Hunan University of Chinese Medicine
机构署名:
本校为第一且通讯机构
院系归属:
护理学院
摘要:
- OBJECTIVE: The aim of this study was to identify sex-specific biomarkers for ischemic stroke (IS) prophylaxis in elderly individuals. MATERIALS AND METHODS: The GSE22255 dataset for elderly individuals with IS was retrieved from the gene expression omnibus database. Thereafter, gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed, as well as gene set enrichment analysis (GSEA). Furthermore, protein-protein interactions (PPIs) were explored using the STRING database, and to screen central genes from the Cytoscape PPI network, correspondin...

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