期刊论文

Experimental Study on Effect of Danggui Buxue Tang（当归补血汤）on TGF-β1 Expression in Kidney of Diabetic Nephropathy Rats

中文

中国中医药科技

1005-7072

2018

25

3

339-340,343

广东省中医药局资助项目（20130601）；

本校为第一机构

目的：观察当归补血汤对实验性糖尿病肾病模型大鼠肾组织TGF-β1表达的影响。方法：50只大鼠,随机分为正常对照组、模型组、当归补血汤组;模型组及当归补血汤组均给予STZ单次腹腔注射,并以隔日高脂饲料喂饲制备糖尿病肾病模型;造模成功后,当归补血汤组给予当归补血汤灌胃,正常组、模型组给予生理盐水灌胃,6周后处死大鼠取肾脏组织,免疫组化方法测定肾组织TGF-β1蛋白表达。结果：与正常组比较,模型组大鼠肾组织TGF-β1表达明显增强（P〈0.01）;当归补血汤组大鼠肾组织TGF-β1表达较模型组明显减弱,差异有统计学意义（P〈0.01）。结论：当归补血汤可以通过抑制肾组织TGF-β1的表达,发挥对糖尿病肾...

Objective： To investigate the effect of Danggui Buxue Tang on TGF-β1 expression in diabetic nephropathy rats. Methods： 50 SD male rats were randomly divided into three groups： normal control group,model group and Danggui Buxue Tang group. Both model group and Danggui Buxue Tang group were injected with single streptozotocin(STZ） intraperitoneally and fed with high fat forage to establish DN model. Rats in Danggui Buxue Tang group were given Danggui Buxue Tang,control and model groups were given the same volume of saline for 6 weeks after m...