Ozone alleviates ischemia/reperfusion injury by inhibiting mitochondrion-mediated apoptosis pathway in SH-SY5Y cells

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成果类型：

期刊论文

作者：

Cai, Hua-An;Tao, Xi;Zheng, Li-Jun;Huang, Liang;Peng, Yan;...

通讯作者：

Liao, RY;Zhu, YM

作者机构：

[Cai, Hua-An] Hunan Normal Univ, Dept Rehabil Med, Lab Sports Med, Hunan Prov Peoples Hosp, Changsha 410016, Peoples R China.

[Cai, Hua-An; Peng, Yan; Zheng, Li-Jun; Huang, Liang; Tao, Xi] Hunan Normal Univ, Affiliated Hosp 1, Changsha 410016, Peoples R China.

[Zheng, Li-Jun; Huang, Liang; Tao, Xi] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Rehabil Med, Changsha 410016, Peoples R China.

[Peng, Yan] Hunan Normal Univ, Hunan Prov Peoples Hosp, Changsha 410016, Peoples R China.

[Liao, RY; Liao, Ruo-Yi] Hunan Univ Chinese Med, Hosp 1, Dept Nursing, Changsha 410007, Peoples R China.

通讯机构：

[Liao, RY ; Zhu, YM ] H

Hunan Univ Chinese Med, Hosp 1, Dept Nursing, Changsha 410007, Peoples R China.

Hunan Prov Key Lab Emergency & Crit Care Metabon, Changsha 410005, Peoples R China.

语种：

英文

关键词：

Cell apoptosis;Cerebral ischemia reperfusion;Mitochondrial damage;Ozone

期刊：

Cell Biology International

ISSN：

1065-6995

年：

2020

卷：

期：

页码：

975-984

DOI：

10.1002/cbin.11294

基金类别：

We would like to give our sincere gratitude to the reviewers for their constructive comments. This work was supported by Scientific Research Projects of Changsha Science and Technology Bureau (No. kq1706051) and Open Research Fund of Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics.

机构署名：

本校为通讯机构

院系归属：

第一中医临床学院

摘要：

AbstractCerebral ischemia/reperfusion (I/R) injuries are common and often cause severe complications. Ozone has been applied for protecting I/R injury in animal models of several organs including cerebra, but the detailed mechanism remains unclear. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay and lactate dehydrogenase measurement were used to determine the influence of ozone on cell activity and damage of SH‐SY5Y cells. Some redox items such as catalase (CAT), malondialdehyde (MDA), glutathione peroxidase (GSH...

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Ozone alleviates ischemia/reperfusion injury by inhibiting mitochondrion-mediated apoptosis pathway in SH-SY5Y cells

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