Qi Fu Yin ameliorates neuroinflammation through inhibiting RAGE and TLR4/NF-KB pathway in AD model rats

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成果类型：

期刊论文

作者：

He, Chunxiang;Yu, Wenjing;Yang, Miao;Li, Ze;Yu, Jingping;...

通讯作者：

Song, Zhenyan;Cheng, SW

作者机构：

[He, Chunxiang; Li, Ze; Song, Zhenyan; Cheng, Shaowu; Song, ZY; Cheng, SW; Yang, Miao; Yu, Wenjing; Deng, Sisi] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

[He, Chunxiang; Li, Ze; Song, Zhenyan; Cheng, Shaowu; Song, ZY; Zhong, Dayuan; Yu, Jingping; Cheng, SW; Yang, Miao; Yu, Wenjing; Deng, Sisi] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410208, Hunan, Peoples R China.

[Yu, Jingping] Baoshan Coll Tradit Chinese Med, Baoshan 678000, Yunnan, Peoples R China.

[Zhong, Dayuan] Guangdong Prov Hosp Integrated Tradit Chinese & We, Foshan 528000, Guangdong, Peoples R China.

通讯机构：

[Song, ZY; Cheng, SW ] H

Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Alzheimer’s disease;RAGE;TLR4/NF-κB signaling pathway;neuroinflammation;traditional Chinese medicine

期刊：

AGING-US

ISSN：

1945-4589

年：

2023

卷：

期：

页码：

13239-13264

DOI：

10.18632/aging.205238

基金类别：

National Natural Science Foundation of China [82074046, 82004184]; Hunan provincial "Shennong Talent" project; Provincial Natural Science Foundation of Hunan [2021JJ40397]; Science and Technology Innovation Program of Hunan Province [2023RC3166]; Natural Science Foundation of Hunan Province for Excellent Youth Project [2023JJ20033]; Natural Science Foundation of Hunan Health Committee [202203105682]; Postgraduate Scientific Research Innovation Project of Hunan Province [QL20220185]

机构署名：

本校为第一机构

院系归属：

中西医结合学院

摘要：

The purpose of this study is to investigate the therapeutic effect of Qi Fu Yin (QFY) on Alzheimer's disease (AD) both computationally and experimentally. Network pharmacology analysis and molecular docking were conducted to identify potential targets and signaling pathways involved in QFY treating AD. Streptozotocin-induced AD rat model was used to verify important targets and predicted pathways. The components of QFY were identified using liquid chromatography-tandem mass spectrometry. The results indicate that the potential targets of QFY ar...

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Qi Fu Yin ameliorates neuroinflammation through inhibiting RAGE and TLR4/NF-KB pathway in AD model rats

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