Because of the better understanding of HIV biology and the limitation of conventional anti-HIV vaccine or drug development,gene therapy to HIV infection is a recent focus in AIDS research.Normal CCR5 protein is required for HIV-1 virus to enter human cells.Individuals with the mutant genotype of CCR5Δ32 are relatively resistant to HIV-1 infection.This paper reviews the application of two engineered enzymes of ZFNs and TENs in th...
