期刊论文

The Effects of Changlong Dan(CLD) on Amino Acid Mediators and Znic in the Brain of Aging Mice

中文

湖南中医药大学学报

1674-070X

2000

20

3

11-13

10.3969/j.issn.1674-070X.2000.03.005

国家教委资助!项目 [（94） 99]；

本校为第一机构

为了研究菖龙丹 （CLD）对衰老小鼠脑内氨基酸类神经递质和锌的影响 ,阐明CLD抗老年性痴呆作用与氨基酸类神经递质的关系。以老年小鼠 （13月龄 ）为实验对象 ,灌胃给予CLD和吡拉西坦 （Pir） ,连续 81d。采用高效液相色谱法测定脑组织中谷氨基 （Glu）、天冬酸 （Asp）和r 氨基丁酸 （GABA）含量 ,以原子吸收分光光度法测定脑组织Zn含量。结果 :老年小鼠脑组织Glu、Asp、GABA的含量均显著降低 （P

To study the effect of CLD on amino acid mediators and Znic in the brain of aging mice and to explain the relationship between the effect of CLD on senile Demention and amino acid mediators. Methods: The change of Glu, Asp and GABA in the brain were studied with HPLC measurement, the changes of Znic with AAS measurement. Results: The Glu, Asp and GABA decreased obviously (P