p Comprehensive Analysis of Tripterine Anti-Ovarian Cancer Effects Using Weighted Gene Co-Expression Network Analysis and Molecular Docking

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成果类型：

期刊论文

作者：

Long, Xi;Liu, Leping;Zhao, Qinyu;Xu, Xinyi;Liu, Pingan;...

通讯作者：

Lin, Jie

作者机构：

[Long, Xi; Xu, Xinyi; Zhang, Guoming; Liu, Leping] Hunan Univ Tradit Chinese Med, Coll Med, Changsha, Hunan, Peoples R China.

[Liu, Leping] Cent South Univ, Dept Blood Transfus, Xiangya Hosp 3, Changsha, Hunan, Peoples R China.

[Zhao, Qinyu] Australian Natl Univ, Coll Engn & Comp Sci, Canberra, ACT, Australia.

[Lin, Jie; Liu, Pingan] Hunan Univ Tradit Chinese Med, Dept Gynecol, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

通讯机构：

[Lin, Jie] H

Hunan Univ Tradit Chinese Med, Dept Gynecol, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Molecular Docking Simulation;Ovarian Cancer;Survival Analysis;Tripterine

期刊：

Medical Science Monitor

ISSN：

1643-3750

年：

2022

卷：

页码：

e932139

DOI：

10.12659/MSM.932139

基金类别：

Hunan Provincial Natural Science Foundation Project [2018112297]; Key Scientific Research Projects of Hunan Provincial Department of Education [19A370, 20A385]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

第一中医临床学院

摘要：

BACKGROUND Ovarian cancer has the highest mortality of gynecological cancers worldwide. The aim of this study was to identify the role of tripterine against ovarian cancer. MATERIAL AND METHODS GSE18520 and GSE12470 data sets were downloaded from the GEO database. WGCNA was used to analyze gene modules and hub genes related to ovarian cancer. These hub genes were intersected with tripterine targets, and GO and KEGG enrichment analyses were performed. HPA and GEPIA determined the expression of tripterine anti-ovarian hub genes in tumor tissues. Kaplan-Meier plotter was used to explore the role ...

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p Comprehensive Analysis of Tripterine Anti-Ovarian Cancer Effects Using Weighted Gene Co-Expression Network Analysis and Molecular Docking

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