期刊论文

Tan, G.-S.

中文

中国药学杂志

1001-2494

2000

35

7

441-443

10.3321/j.issn:1001-2494.2000.07.004

本校为其他机构

鉴定川东獐牙菜4个化合物，分别为苦龙胆酯苷（amarogentin，I）、雏菊叶龙胆苷（swertianolin，II）、去甲基雏菊叶龙胆酮（demethylbellidifolin，III）和雏菊叶龙胆酮（bellidifolin，IV）。II，III均为首次从本植物中分离得到，首次利用2D-NMR实验技术对的波谱数据进行了系统归属。

Objective: To study the active constituents of Swertia davidi Franch. Methods: The raw compounds were isolated by using column chromatography with silica gel and sephadex LH-20. Their structures were confirmed by IR, MS, 1H and 13C-NMR and/or 1H-13C COSY. Results: Four compounds were elucidated as amarogentin, swertianolin, demethylbellidifollin and bellidifolin, respectively. Conclusion: Swertianolin and demethylbellidifolin were first time isolated from this plant. The structure of amarogentin was elucidated by two-dimensional nuclear magnetic r...