期刊论文

Xiang, D.-X.(xiangdaxiong@netease.com)

中文

中国药学杂志

1001-2494

2005

40

7

532-534

10.3321/j.issn:1001-2494.2005.07.017

湖南省科技厅科技攻关项目

本校为其他机构

目的 研究葛根总黄酮(TPF)生物黏附性缓释片和普通片在家犬体内的药动学与生物利用度，揭示葛根总黄酮生物黏附性缓释片在家犬体内的药动学变化规律，为临床合理运用该药提供实验依据?方法健康家犬6只，以自身前后交叉对照方式，单剂量分别给予葛根总黄酮生物黏附性缓释片和普通片600mg。葛根素血药浓度经时数据以3P87药动学程序处理，以对两种片剂在家犬体内的动态过程进行拟合，以非室模型统计矩方法，计算药时曲线下面积(AUC0→2)，并由血药浓度数据读取Cmax，tmax，经统计分析比较普通片与缓释片的生物利用度。结果单剂量给予家犬TPF片及生物黏附片后，葛根素血药浓度变化符合一级吸收一室模...

OBJECTIVE: To study the pharmacokinetics and bioavailability of total puerariae flavones (TPF) bioadhesive sustained-release tablets in dogs. METHODS: Blood samples were obtained at 0, 0.25, 1.0, 1.5, 2.0, 3.0, 4.0, 7.0, 9.0, 12 h after a single dose of 600 mg TPF tablets and TPF bioadhesive sustained-release of tablets, puerarin concentration was determined by HPLC. The pharmacokinetics of puerarin were analyzed by 3P87 program. RESULTS: The concentration-time profile in dog plasma was discribed with a two-compartment model. The main pharmacokinetic parameters of puerarin in TPF tablets and T...