期刊论文

He, Q.

中文

中国药学杂志

1001-2494

2015

50

17

1532-1535

10.11669/cpj.2015.17.016

国家科技部支撑计划（2008BAI53B042）；

本校为第一且通讯机构

目的为解决湿疹乳膏暴露过程中失水开裂的问题,对该制剂中保湿剂(甘油)的最佳用量进行筛选。方法配制8份不同用量的甘油样品,测定不同温度,不同时间的失水百分率,建立每个温度下每组样品失水百分率随时间变化的动力学方程,求算失水速度常数,采用等级一致性检验法,比较不同温度下8份湿疹乳膏样品失水速度差别,得出保湿剂(甘油)的最优用量。结果实验及统计分析结果表明,各样品在不同温度下的数学表达式皆为幂函数模型,方程的斜率即为失水速度常数。等级有一致性的倾向,即各温度下各样品的失水速度常数有显著性差异(P < 0.05),湿疹乳膏中保湿剂(甘油)用量为13.6%时等级和Ri最大,保湿效果最佳。结论...

OBJECTIVE: To determine the optimum amount of humectant (glycerin) in eczema cream to solve the water loss and cracking problem during storage. METHODS: Eight eczema cream samples with different dosages of glycerol were prepared. The percentage of water loss was determined, and the dynamic equations at different temperatures for different times were established. The constant of water loss rate was calculated, the speed of water loss was compared for the eight samples with the method of test for grade consistency, and the optimal amount of humec...