期刊论文

Application of TOPSIS Comprehensive Evaluation Method in Preparation of Xiaoerjianpiwentong Plaster

Zuo, Y.-J.

中文

中国药学杂志

1001-2494

2017

52

5

398-403

10.11669/cpj.2017.05.013

湖南省科技计划重点项目(2013SK2026) 长沙市科技计划重点项目(k1307164-31)

本校为第一且通讯机构

目的采用逼近于理想值的排序法(TOPSIS)综合评价法,优选小儿健脾温通贴的制剂工艺。方法以色泽、均匀性、皮肤追随性、剥离强度等为质量评价指标,并赋以相应的权重,采用TOPSIS综合评价法进行评分;对8篇代表性文献进行复制,筛选凝胶贴膏基质的种类与制法;采用单因素试验结合TOPSIS综合评价法,优选贴膏的处方用量,并对其进行验证性试验。结果小儿健脾温通贴的最佳处方为明胶-聚乙烯吡咯烷酮K-30-聚丙烯酸钠-甘油-氮酮-干膏粉-挥发油= 2∶ 1∶ 2.5∶ 12∶ 1∶ 1∶ 0.234(m/m)。结论以最优处方基质配比制备的凝胶贴膏,外观均匀,剥离强度适宜,成形性优,稳定性好。

OBJECTIVE: To screen the preparation technology of Xiaoerjianpiwentong plaster using the technique for order preference by similarity to ideal solution (TOPSIS) comprehensive evaluation method. METHODS: Using color, uniformity, adhesive ability, and peeling strength as the quality control indexes with different weighting factors, plasters of different prescriptions were scored by the TOPSIS comprehensive evaluation method. Experiments were conducted to repeat eight representative literatures to select the matrix and preparation process for the gel plaster. Single factor experiment was performe...