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Protective effects and mechanisms of Yi Qi Huo Xue Fang in cerebral ischemic stroke based on network pharmacology and experimental verification

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成果类型:
期刊论文
作者:
Li, Jiamin;Zhang, Tiantian;Liu, Kan;Hu, Guoheng
通讯作者:
Hu, GH
作者机构:
[Zhang, Tiantian; Liu, Kan; Li, Jiamin; Hu, Guoheng] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha 410021, Peoples R China.
[Zhang, Tiantian; Li, Jiamin; Hu, Guoheng] Hunan Univ Chinese Med, Changsha 410208, Peoples R China.
通讯机构:
[Hu, GH ] H
Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha 410021, Peoples R China.
语种:
英文
关键词:
Angiogenesis;Cerebral ischemic stroke;Microglia;Network pharmacology;PPARG;Yi Qi Huo Xue Fang
期刊:
Journal of Ethnopharmacology
ISSN:
0378-8741
年:
2023
卷:
314
页码:
116611
基金类别:
Natural Science Foundation of Hunan Province [2020JJ4476]; Scientific Research Project of Hunan Provincial Education Department [19A379]; Scientific Research Project of Hunan Provincial Health and Family Planning Commission [20201617]; Hunan Province's domestic first-class construction discipline TCM discipline project [2022ZYX13]; Open Fund of First-class Discipline of Chinese Medicine of Hunan University of Chinese Medicine [2021ZYX40]; Quality Project of Postgraduate Training of Hunan University of Chinese Medicine [2021CX19]
机构署名:
本校为第一且通讯机构
院系归属:
第一中医临床学院
摘要:
ETHNOPHARMACOLOGICAL RELEVANCE: Yi Qi Huo Xue Fang (YQHXF) is an effective formula for treating cerebral ischemic stroke (CIS). However, its active ingredients and mechanism of action remain unclear. AIM OF THE STUDY: This study aimed to reveal the mechanism of action of YQHXF in the treatment of ischemic stroke based on network pharmacology and experimental validation. MATERIALS AND METHODS: This study identified the chemical components in YQHXF and the components absorbed by rat serum based on UPLC-Q-TOF/MS technology and used network pharmac...

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