Expression of acetylated histone 3 in the spinal cord and the effect of morphine on inflammatory pain in rats

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成果类型：

期刊论文

作者：

Li, Hua（李花）;Li, Changqi;Dai, Ruping;Shi, Xudan;Xu, Junmei;...

通讯作者：

Luo, Xuegang

作者机构：

[Li, Hua; Li, Zhiyuan; Li, Changqi; Zhang, Jianyi; Luo, Xuegang] Cent S Univ, Xiangya Sch Med, Dept Anat & Neurobiol, Changsha 410013, Hunan, Peoples R China.

[Li, Hua] Hunan Univ Tradit Chinese Med, Dept Histol & Embryol, Changsha 410208, Hunan, Peoples R China.

[Xu, Junmei; Dai, Ruping; Shi, Xudan] Cent S Univ, Xiangya Hosp 2, Dept Anesthesia, Changsha 410013, Hunan, Peoples R China.

[Zhou, Xinfu] Flinders Univ S Australia, Dept Human Physiol, Adelaide, SA, Australia.

通讯机构：

[Luo, Xuegang] C

Cent S Univ, Xiangya Sch Med, Dept Anat & Neurobiol, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

inflammation;hyperalgesia;acetylated histone 3;spinal cord;morphine;neurobiology

关键词(中文)：

脊髓背角神经元;组蛋白;乙酰化;炎性痛;大鼠;吗啡;星形胶质细胞;神经胶质细胞

期刊：

中国神经再生研究：英文版

ISSN：

1673-5374

年：

2012

卷：

期：

页码：

517-522

DOI：

10.3969/j.issn.1673-5374.2012.07.007

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070897, 81102726]

机构署名：

本校为其他机构

院系归属：

医学院

中医学院

摘要：

In this study, a rat model of inflammatory pain was produced by injecting complete Freund’s adjuvant into the hind paw, and the expression of acetylated histone 3 in the spinal cord dorsal horn was examined using immunohistochemical staining. One day following injection, there was a dramatic decrease in acetylated histone 3 expression in spinal cord dorsal horn neurons. However, on day 7, expression recovered in adjuvant-injected rats. While acetylated histone 3 labeling was present in dorsal horn neurons, it was more abundant in astrocytes an...

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Expression of acetylated histone 3 in the spinal cord and the effect of morphine on inflammatory pain in rats

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