Role of Paraoxonase-1 in the Protection of Hydrogen Sulfide-Donating Sildenafil (ACS6) Against Homocysteine-Induced Neurotoxicity

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tang, Xiao-Qing*;Chen, Rong-Qian;Dong, Ling;Ren, Yan-Kai;Del Soldato, Piero;...

通讯作者：

Tang, Xiao-Qing

作者机构：

[Ren, Yan-Kai; Chen, Rong-Qian; Tang, Xiao-Qing] Univ South China, Coll Med, Inst Cognit & Nervous Syst Dis, Hengyang 421001, Hunan, Peoples R China.

[Ren, Yan-Kai; Tang, Xiao-Qing] Univ South China, Coll Med, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

[Liao, Duan-Fang] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha 420108, Hunan, Peoples R China.

[Del Soldato, Piero] CTG Pharma, I-20131 Milan, Italy.

[Sparatore, Anna] Univ Milan, Dept Pharmaceut Sci Pietro Pratesi, Milan, Italy.

通讯机构：

[Tang, Xiao-Qing] U

Univ South China, Coll Med, Inst Cognit & Nervous Syst Dis, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

H2S-releasing sildenafil;Homocysteine;Neurotoxicity;Paraoxonase-1;Reactive oxygen species

期刊：

Journal of Molecular Neuroscience

ISSN：

0895-8696

年：

2013

卷：

期：

页码：

70-77

DOI：

10.1007/s12031-012-9862-x

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81071005, 30770740]; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education MinistryScientific Research Foundation for the Returned Overseas Chinese Scholars [[2010]508]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

ACS6, a novel hydrogen sulfide (H2S)-releasing sildenafil, has been demonstrated to inhibit superoxide formation through donating H2S. We have previously found that ACS6 antagonizes homocysteine-induced apoptosis and cytotoxicity. The aim of the present study is to explore the molecular mechanisms underlying ACS6-exerted protective action against the neurotoxicity of homocysteine. In the present work, we used PC12 cells to explore whether paraoxonase-1 (PON-1) is implicated in ACS6-induced neuroprotection against homocysteine neurotoxicity. We show that ACS6 treatment results in prevention of ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Role of Paraoxonase-1 in the Protection of Hydrogen Sulfide-Donating Sildenafil (ACS6) Against Homocysteine-Induced Neurotoxicity

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问