Integrated metabolomics and network pharmacology to reveal the mechanisms of hydroxysafflor yellow A against acute traumatic brain injury

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成果类型：

期刊论文

作者：

Li, Teng;Zhang, Wei;Hu, En;Sun, Zhengji;Li, Pengfei;...

通讯作者：

Wang, Y

作者机构：

[Xia, Zian; Zhu, Xiaofei; Luo, Jiekun; Hu, En; Wang, Yang; Yu, Zhe; Xing, Zhihua; Tang, Tao; Li, Teng] Cent South Univ, Xiangya Hosp, Dept Integrated Tradit Chinese & Western Med, Inst Integrat Med, Changsha 410008, Peoples R China.

[Zhang, Wei; Zheng, Fei; Sun, Zhengji] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Peoples R China.

[Li, Pengfei] Zhengzhou Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Zhengzhou 450052, Peoples R China.

[He, Feng] Cent South Univ, Xiangya Hosp, Dept Hepatobiliary Surg, Changsha 410008, Peoples R China.

通讯机构：

[Wang, Y ] C

Cent South Univ, Xiangya Hosp, Dept Integrated Tradit Chinese & Western Med, Inst Integrat Med, Changsha 410008, Peoples R China.

语种：

英文

关键词：

Traumatic brain injury;Hydroxysafflor yellow A;Metabolomics;Network pharmacology;Mechanisms

期刊：

Computational and Structural Biotechnology Journal

ISSN：

2001-0370

年：

2021

卷：

页码：

1002-1013

DOI：

10.1016/j.csbj.2021.01.033

基金类别：

This study was funded by grants from the National Natural Science Foundation of China (No. 81973665, 81673719, 81874409 and 81803948), Hunan Provincial Natural Science Foundation of China (No. 2019JJ30042), The Outstanding Youth Fund of Hunan Natural Science (No. 2020JJ2024), and Innovation-Driven Project of Central South University (No. 2020CX047).

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

Traumatic brain injury (TBI) has become a leading cause of mortality, morbidity and disability worldwide. Hydroxysafflor yellow A (HSYA) is effective in treating TBI, but the potential mechanisms require further exploration. We aimed to reveal the mechanisms of HSYA against acute TBI by an integrated strategy combining metabolomics with network pharmacology. A controlled cortical impact (CCI) rat model was established, and neurological functions were evaluated. Metabolomics of brain tissues was used to identify differential metabolites, and the metabolic pathways were enriched by MetaboAnalyst...

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Integrated metabolomics and network pharmacology to reveal the mechanisms of hydroxysafflor yellow A against acute traumatic brain injury

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