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Bufotalin loaded biomimetic nanodrug for combined chemo/photodynamic therapy of cancer

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成果类型:
期刊论文
作者:
"Chen, Simin;Fan, Jialong;Xie, Qian;Qin, Yan;Xie, Hailong;...
通讯作者:
Wei Wang
作者机构:
["Chen, Simin; Xiao, Chang; Liu, Bin"] College of Biology, Hunan University, Changsha, 410082, China
[Wang, Wei] TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China
[Xie, Hailong] Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Institute of Cancer Research, School of Medicine, University of South China, Hengyang, 421001, China
Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha, 410219, China
[Xie, Qian] Hunan Provincial Maternal and Child Health Care Hospital, Hunan Province, Changsha 410008, China
通讯机构:
[Wei Wang] T
TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China
语种:
英文
关键词:
Bufotalin;Cancer;Chlorin e6;Combination therapy;Prussian blue nanoparticles
期刊:
Materials Today Bio
ISSN:
2590-0064
年:
2025
卷:
32
页码:
101684
机构署名:
本校为通讯机构
院系归属:
药学院
摘要:
The combination of chemotherapy and photodynamic therapy (PDT) for enhancing cancer therapeutic efficiency has attracted tremendous attention recently. However, limitations, such as low local concentration and uncontrollable release of therapeutic agents, reduce combined treatment efficacy. In the present study, we engineered a biomimetic nanodrug employing hollow Prussian blue nanoparticles (HPB NPs) to co-load the chemical agent bufotalin (CS-5) and the photosensitizer chlorin e6 (Ce6) for combined chemo/PDT therapy against cancer. HPB NPs with catalase (CAT)-mimetic activity significantly i...

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