期刊论文

Experimental study of Shenji huwei granules in preventing reserpine-induced gastric ulcer in rats

中文

现代医药卫生

1009-5519

2014

30

3

327-328+331

10.3969/j.issn.1009-5519.2014.03.003

本校为第一机构

目的 通过观察参积护胃颗粒对利血平型大鼠胃黏膜损伤的保护作用,探讨参积护胃颗粒防治大鼠胃溃疡的作用.方法 将60只健康SD大鼠分为对照组,模型对照组,奥美拉唑组,参积护胃颗粒低、中、高3个剂量组共六组,每组10只,雌雄各半,奥美拉唑组和参积护胃颗粒低、中、高剂量组的给药剂量分别为4.17 mg/kg和2.61、5.22、10.44 g/kg,其余两组予以等体积蒸馏水,灌胃7 d,每天1次,末次灌胃后腹腔注射利血平(5 mg/kg)复制胃溃疡模型,观察胃黏膜的损伤情况,计算溃疡指数和各组溃疡发生率,并取腺胃进行病理切片检测.结果 与模型对照组比较,奥美拉唑组和参积护胃颗粒中、高剂量组均能显著降低胃溃疡指数,差异有统...

Objective Through the observation of Shenji huwei granules on reserpine-induced gastric mucosal lesion in rats, to discuss the role of Shenji huwei granules in prevention and treatmeat of rat＇ s gastric ulcer. Methods A total of 60 rats were divided into 6 groups with 10 cases in each group and sex in half：control group,model control group,omeprazole （OME） group, Shenji huwei granules group with low, middle and high dose. The OME group was treated with the dosage of 4.17 mg/kg, the Shenji huwei granules group with low, middle and high dose ...