Oxypeucedanin hydrate monoacetate isolated from Angelica dahurica induces apoptosis in Caco-2 colon carcinoma cells through the mediation of PI3K-signalling pathway and inhibition of cancer cell migration
Graduate Student Research Innovation Project in Hunan Province [CX2014B356]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81173263]
机构署名：
本校为第一且通讯机构
院系归属：
第一中医临床学院
第二中医临床医学院
摘要：
The main aim of the present research work was to demonstrate the antitumor and apoptotic activities of oxypeucedanin hydrate monoacetate isolated from Angelica dahurica against Caco-2 colon cancer cells. MTT cell viability assay along with clonogenic assays were used to study the effect of the compound on cell cytotoxicity and the colony forming tendency. Fluorescence microscopy using acridine orange/ethidium bromide was used to study the effects on apoptosis. In vitro wound healing assay and Western blotting were carried out to study effect on...
