The novel role and underlying mechanism of Wnt5a in regulating cellular cholesterol accumulation

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成果类型：

期刊论文

作者：

Qin, Li;Hu, Rong;Zhu, Neng;Yao, Hai-Lun;Lei, Xiao-Yong;...

通讯作者：

Liao, Duan-Fang

作者机构：

[Li, Shun-Xiang; Zheng, Xi-Long; Liao, Duan-Fang; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Yao, Hai-Lun; Lei, Xiao-Yong; Hu, Rong; Qin, Li] South China Univ, Inst Pharm & Pharmacol, Changsha, Hunan, Peoples R China.

[Zhu, Neng] Cent South Univ, Xiangya Hosp 2, Dept Urol, Changsha, Hunan, Peoples R China.

[Zhu, Neng] South China Univ, Dept Urol, Affiliated Hosp 2, Hengyang, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Fac Med, Dept Biochem & Mol Biol, Smooth Muscle Res Grp,Libin Cardiovasc Inst Alber, Calgary, AB, Canada.

通讯机构：

[Liao, Duan-Fang] H

Hunan Univ Chinese Med, 1 Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

ATP-binding cassette transporter A1 (ABCA1);Wnt5a;caveolin-1;cholesterol accumulation

期刊：

Clinical and Experimental Pharmacology and Physiology

ISSN：

0305-1870

年：

2014

卷：

期：

页码：

671-678

DOI：

10.1111/1440-1681.12258

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000946, 81270359, 81173047]; Construct Program of the Key Discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

Cholesterol accumulation is a critical step during the development and progression of atherosclerosis. Recently, Wnt5a expression has been found to be markedly upregulated in both murine and human atherosclerotic lesions. However, the effect and mechanism of Wnt5a in atherosclerosis is poorly understood. In the present study, we investigated the effects and potential mechanisms of Wnt5a on cholesterol accumulation during atherosclerosis. We used RAW264.7 and vascular smooth muscle cells (VSMC) treated with oxidized low-density lipoprotein (oxLD...

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The novel role and underlying mechanism of Wnt5a in regulating cellular cholesterol accumulation

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