Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism

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成果类型：

期刊论文

作者：

Wu, Ling;Chen, Hong-Yao;Zhang, Jing-Ting;Yang, Ren-Yi;Wang, Zhi-Bin;...

通讯作者：

Zeng, PH

作者机构：

[Chen, Hong-Yao; Wu, Ling; Xue, Pei-Sen; Wang, Zhi-Bin; Yang, Ren-Yi; Zhang, Jing-Ting; Gao, Wen-Hui] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Peng, Wei; Li, Ke-Xiong] Hunan Prov Hosp Integrated Tradit Chinese & Wester, Dept Oncol, Changsha 410006, Hunan, Peoples R China.

[Zeng, Pu-Hua] Hunan Acad Tradit Chinese Med, Hunan Prov Hosp Integrated Tradit Chinese & Wester, Canc Res Inst, 58 Lushan Rd, Changsha 410006, Hunan, Peoples R China.

通讯机构：

[Zeng, PH ] H

Hunan Acad Tradit Chinese Med, Hunan Prov Hosp Integrated Tradit Chinese & Wester, Canc Res Inst, 58 Lushan Rd, Changsha 410006, Hunan, Peoples R China.

语种：

英文

关键词：

Bioinformatics;Chlorogenic acid;Ferroptosis;Hepatocellular carcinoma;In vitro experiment;Prostaglandin endoperoxide synthase 2/aldo-keto reductase family 1 member C3/glutathione peroxidase 4 axis

期刊：

世界胃肠肿瘤学杂志：英文版(电子版)

ISSN：

1948-5204

年：

2025

卷：

期：

页码：

98844

DOI：

10.4251/wjgo.v17.i3.98844

基金类别：

National Natural Science Foundation of China [82074425]; Natural Foundation of Hunan Province [2023JJ30364, 2023JJ30361]; Hunan Provincial Key RD Program [2023SK2057]; Key Project of Hunan Provincial Administration of Traditional Chinese Medicine [A2023042]

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

摘要：

BACKGROUND: Ferroptosis is an iron-dependent programmed non-apoptotic cell death characterized by the accumulation of free iron ions and lipid peroxidation. It is associated with the inactivation of glutathione peroxidase (GPX) and the accumulation of lipid peroxides within cells. Ferroptosis is closely related to the occurrence and development of hepatocellular carcinoma (HCC). Chlorogenic acid (CGA), an important bioactive component found in 61 traditional Chinese medicines such as Eucommia ulmoides, has been extensively studied for its effects on various malignant tumors. However, the speci...

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Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism

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