Naotaifang formula attenuates OGD/R-induced inflammation and ferroptosis by regulating microglial M1/M2 polarization through BMP6/ SMADs signaling pathway

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成果类型：

期刊论文

作者：

Liao, Jun*;Wei, Mengzhen;Wang, Jianjun;Zeng, Jinsong;Liu, Danhong;...

通讯作者：

Liao, Jun;Ge, Jinwen;Mei, ZG

作者机构：

[Ge, Jinwen; Mei, Zhigang; Liao, Jun; Liao, J] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410208, Hunan, Peoples R China.

[Wang, Jianjun; Liu, Danhong; Du, Qiusi; Wei, Mengzhen; Liao, Jun] Hunan Univ Chinese Med, Med Coll, Vasc Biol Lab, Changsha 410208, Hunan, Peoples R China.

[Zeng, Jinsong] Hunan Univ Chinese Med, Neurosurg Dept, Hosp 1, Changsha 410007, Hunan, Peoples R China.

[Ge, Jinwen] Hunan Acad Tradit Chinese Med, Changsha 410031, Hunan, Peoples R China.

通讯机构：

[Ge, JW; Mei, ZG ; Liao, J] H

Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

BMP6/SMADs;Ferroptosis;Microglia;Naotaifang;Neuroinflammation;OGD/R

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2023

卷：

167

页码：

115465

DOI：

10.1016/j.biopha.2023.115465

基金类别：

National Natural Science Foundation of China [81774033]; Natural Science Foundation of Hunan Province [2021JJ30496, 2021JJ30499]; Key Projects of Hunan Province Educa-tion Department [20A362]; Innovation Project for Graduate Students at Hunan University of Chinese Medicine [2022CX178]

机构署名：

本校为其他机构

院系归属：

医学院

第一中医临床学院

摘要：

BACKGROUND: Cerebral ischemia-reperfusion injury (CIRI), a subsequent injury caused by thrombolytic reperfusion post ischemic stroke (IS). Naotaifang (NTF) formula, a novel traditional Chinese medicine (TCM) remedy against IS, was shown to exert beneficial effects in inhibiting inflammation and inhibiting lipid peroxide synthesis in our previous research. PURPOSE: This study aimed to further explore the role of NTF in attenuating oxygen-glucose deprivation//reoxygenation (OGD/R)-induced inflammation and ferroptosis by regulating microglial M1/M...

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Naotaifang formula attenuates OGD/R-induced inflammation and ferroptosis by regulating microglial M1/M2 polarization through BMP6/ SMADs signaling pathway

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