Bu-Shen-Huo-Xue Decoction Ameliorates Diabetic Nephropathy by Inhibiting Rac1/PAK1/p38MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

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成果类型：

期刊论文

作者：

Wang, Weisong;Long, Hongping;Huang, Wei;Zhang, Ting;Xie, Lihua;...

通讯作者：

Liu, Jianhe;Xiong, Dan;Hu, Wei

作者机构：

[Zhang, Ting; Huang, Wei; Chen, Cheng; Xie, Lihua; Wang, Weisong] Hunan Univ Chinese Med, Grad Sch, Changsha, Peoples R China.

[Long, Hongping] Hunan Univ Chinese Med, Hosp 1, Expt Ctr Med Innovat, Changsha, Peoples R China.

[Liu, Jianhe] Hunan Univ Chinese Med, Hosp 1, Dept Cardiol, Changsha, Peoples R China.

[Xiong, Dan] Hunan Univ Chinese Med, Hosp 1, Dept Nephrol, Changsha, Peoples R China.

[Hu, Wei] Hunan Univ Chinese Med, Hosp 1, Dept Endocrinol, Changsha, Peoples R China.

通讯机构：

[Liu, Jianhe; Xiong, Dan; Hu, Wei] H

Hunan Univ Chinese Med, Hosp 1, Dept Cardiol, Changsha, Peoples R China.

Hunan Univ Chinese Med, Hosp 1, Dept Nephrol, Changsha, Peoples R China.

Hunan Univ Chinese Med, Hosp 1, Dept Endocrinol, Changsha, Peoples R China.

语种：

英文

关键词：

diabetic nephropathy;Bu-Shen-Huo-Xue decoction;podocyte epithelial-mesenchymal transition;Rac1;PAK1;p38MAPK

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2020

卷：

页码：

587663

DOI：

10.3389/fphar.2020.587663

基金类别：

This study was supported by the Natural Science Foundation of Hunan Province (2020JJ8024), the Open Fund of Key Laboratory of the Ministry of Education of China for Prevention and Transformation of Major Diseases in Internal Medicine of TCM (ZYNK201704), and the Scientific Research Fund Project of Hunan University of Chinese Medicine (ZYYDX201742).

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

研究生院

摘要：

Diabetic nephropathy (DN), a leading cause of end-stage renal disease, is associated with high morbidity and mortality rates worldwide and the development of new drugs to treat DN is urgently required. Bu-Shen-Huo-Xue (BSHX) decoction is a traditional Chinese herbal formula, made according to traditional Chinese medicine (TCM) theory, and has been used clinically to treat DN. In the present study, we established a high-fat diet/streptozotocin-induced diabetic mouse model and treated the mice with BSHX decoction to verify its therapeutic effects in vivo. Ultraperformance liquid chromatography c...

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Bu-Shen-Huo-Xue Decoction Ameliorates Diabetic Nephropathy by Inhibiting Rac1/PAK1/p38MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

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