期刊论文

中文

中国中医药信息杂志

1005-5304

2003

10

10

30-31

10.3969/j.issn.1005-5304.2003.10.016

教育部青年骨干教师科研基金资助项目（№.200065）；

本校为第一机构

目的:观察血府逐瘀汤对急性心肌缺血犬缺血心肌的保护作用.方法:采用结扎冠状动脉左前降支的方法复制急性心肌缺血模型,实验结束后检测肌酸磷酸激酶(CPK)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)、丙二醛(MDA),观察心肌组织病理学变化.结果:心肌缺血组CPK、LDH含量及MDA水平均明显升高,SOD水平下调,与对照组比较均有显著差异(P＜0.05),形态学观察示心肌细胞坏死增多.血府逐瘀汤组CPK、LDH含量及MDA水平均低于缺血组,SOD水平上调,与缺血组比较有显著差异(P＜0.05),与对照组比较无显著差异,形态学观察示心肌坏死程度较低.结论:血府逐瘀汤可有效降低CPK、LDH含量及MDA水平,提高SOD水平,减少心肌细胞...

Objective:To explore the protective effect of XFZHY decoction on experimental ischemic myocardium. Methods:The left anterior descending coronary artery was ligated to make a model of acute ischemic myocardium. Results:The SOD activity of XFZhY group were significantly higher than those of ischemic group. The level of CPK、LDH and MDA of XFZhY group were significantly lower than those of ischemic group. The number of myocyte necrotic cell increased in ischemic group. C...