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The Acute Toxicity and Cardiotoxic Effects of Levofloxacin on Zebrafish (Danio rerio)

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成果类型:
期刊论文
作者:
Wu, Yixiao;Yu, Wenjing;Song, Zhenyan;He, Jiawei;Li, Ze;...
通讯作者:
Cheng, SW
作者机构:
[Li, Ze; Song, Zhenyan; Cheng, Shaowu; He, Jiawei; Li, Ping; Wu, Yixiao; Cheng, SW; Chen, Qi; Wang, Shiwei; Yu, Wenjing] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha 410208, Peoples R China.
[Li, Ze; Song, Zhenyan; He, Jiawei; Li, Ping; Wu, Yixiao; Chen, Qi; Wang, Shiwei; Yu, Wenjing] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410208, Peoples R China.
[Cheng, Shaowu; Cheng, SW] Hunan Univ Chinese Med, Hunan Univ Tradit Chinese Med, Affiliated Hosp 2, Changsha 410208, Peoples R China.
[Cheng, Shaowu; Cheng, SW] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Peoples R China.
通讯机构:
[Cheng, SW ] H
Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha 410208, Peoples R China.
Hunan Univ Chinese Med, Hunan Univ Tradit Chinese Med, Affiliated Hosp 2, Changsha 410208, Peoples R China.
Hunan Univ Chinese Med, Sch Med, Changsha 410208, Peoples R China.
语种:
英文
关键词:
levofloxacin;zebrafish;embryotoxicity;cardiotoxicity;emerging contaminants;gene expression
期刊:
Toxics
ISSN:
2305-6304
年:
2025
卷:
13
期:
2
页码:
122-
基金类别:
Conceptualization, S.C.; methodology, Z.S.; software, W.Y.; validation, Y.W. and J.H.; formal analysis, Y.W.; investigation, Z.L.; resources, S.C.; data curation, S.W.; writing—original draft preparation, Y.W. and S.C.; writing—review and editing, W.Y. and P.L.; visualization, Q.C. and P.L.; supervision, P.L.; project administration, S.C.; funding acquisition, S.C. All authors have read and agreed to the published version of the manuscript. This research was funded by the National Natural Science Foundation of China (Grant No. 82074046); the Hunan provincial “Shennong Talent” project; the Science and Technology Innovation Program of Hunan Province (Grant No.2023RC3166,2024RC1060); the Natural Science Foundation of Hunan Province for Excellent Youth Project (Grant No.2023JJ20033); the Scientific Research Fund of Hunan Provincial Education Department (Grant No.23A0297, 23B0373); the Provincial Discipline Construction Project of Hunan University of Chinese Medicine (Integrated Traditional Chinese and Western Medicine) (Grant No.22JBZ015); and the Postgraduate Scientific Research Innovation Project of Hunan Province (Grant No.2024CX048,2024CX013).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
第二中医临床医学院
中西医结合学院
摘要:
Emerging contaminants refer to chemical substances that have not been widely regulated but possess the potential to cause adverse effects on both the environment and human health. Antibiotics, as emerging contaminants, pose significant threats to ecosystems and human health due to their widespread use and persistence in the environment. Levofloxacin, a broad-spectrum fluoroquinolone antibiotic, is commonly employed in the treatment of bacterial infections, and has been frequently detected in environmental matrices and freshwater systems. In this study, we assessed the effects of levofloxacin o...

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