期刊论文

Wang, Yuhong

英文

Cancer Management and Research

1179-1322

2020

12

13003-13014

10.2147/CMAR.S279800

This work was supported by the major science and technology project for “Significant New Drugs Creation” (2017ZX09309026), the National Natural Science Foundation of China Grants (81874464), the Key Projects of Hunan Science and T echnology Department (2018DK2014), the Research and innovation project of graduate students in Hunan Province (CX2018B480) and the Subsidized Project of T op-Ranking Discipline Construction of T raditional Chinese Medicine in Hunan University of Chinese Medicine.

本校为第一且通讯机构

Background: Breast cancer is one of the most common cancer with high risk in females all over the world. It is usually complicated with depression, which can further accelerate the development and progression of breast tumors. We aim to identify a new drug and identify its functional mechanism in the regulation of hippocampal microglia (MG) in breast cancer complicated with depression (BCCD). Methods: The activation model of MG was established by treatments from corticosterone (CORT) or lipopolysaccharides (LPS). The inhibitory effects of resat...