Antidepressive effects of ginsenoside Rg1 via regulation of HPA and HPG axis

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成果类型：

期刊论文

作者：

Mou, Zheng;Huang, Qian;Chu, Shi-feng;Zhang, Mei-Jin;Hu, Jin-Feng;...

通讯作者：

Chen, Nai-hong;Zhang, Jun-tian

作者机构：

[Zhang, Mei-Jin; Zhang, Jun-tian; Huang, Qian; Mou, Zheng; Chen, Nai-hong; Hu, Jin-Feng] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Zhang, Mei-Jin; Zhang, Jun-tian; Huang, Qian; Mou, Zheng; Chen, Nai-hong; Hu, Jin-Feng] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

[Zhang, Mei-Jin; Zhang, Jun-tian; Huang, Qian; Chen, NH; Mou, Zheng; Chen, Nai-hong; Hu, Jin-Feng] Peking Union Med Coll, 1 Xiannongtan St, Beijing 100050, Peoples R China.

[Chen, Nai-hong; Chu, Shi-feng] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.

[Chen, NH; Zhang, Jun-tian] Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, 1 Xiannongtan St, Beijing 100050, Peoples R China.

通讯机构：

[Chen, NH; Zhang, JT] P

[Chen, NH; Zhang, JT] C

Peking Union Med Coll, 1 Xiannongtan St, Beijing 100050, Peoples R China.

Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, 1 Xiannongtan St, Beijing 100050, Peoples R China.

语种：

英文

关键词：

Depression;Ginsenoside rg1;GR;Testosterone;AR

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2017

卷：

页码：

962-971

DOI：

10.1016/j.biopha.2017.05.119

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81260650, 81274122, U1402221, 81573636, 81560663]; Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)Program for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT1007]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7131013, 7142115]; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study [BZ0150]; Fundamental Scientific Research Funds for Central Public Institute [2014RC03]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Background Hypothalamic–pituitary–adrenal (HPA) axis hyperactivity is a well-established pathological feature of major depression, accompanied by the persistent increase of glucocorticoid level and the dysfunction of hypothalamic–pituitary–gonadal (HPG) axis. Ginsenoside Rg1 (Rg1) is one of the most active ingredients of Panax ginseng, which has various biological activity. Objective This study aimed to investigate the antidepressive effects of Rg1 and elucidate its impact on neuroendocrine system. Methods The antidepressive effects of Rg1 ...

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