版权说明 操作指南
首页 > 成果 > 详情

The potential role of microRNA-124 in cerebral ischemia injury

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Liu, Xiaolu;Feng, Zhitao;Du, Lipeng;Huang, Yaguang;Ge, Jinwen;...
通讯作者:
Mei, ZG
作者机构:
[Du, Lipeng; Liu, Xiaolu; Mei, Zhigang; Feng, Zhitao; Huang, Yaguang] China Three Gorges Univ, Grade Pharmacol Lab Chinese Med 3, State Adm Tradit Chinese Med, Med Coll, Yichang 443002, Peoples R China.
[Deng, Yihui; Mei, Zhigang; Ge, Jinwen] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Mei, ZG ] C
China Three Gorges Univ, Grade Pharmacol Lab Chinese Med 3, State Adm Tradit Chinese Med, Med Coll, Yichang 443002, Peoples R China.
Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
apolipoprotein A1;beta secretase 1;BIM protein;brain derived neurotrophic factor;caveolin 1;CCAAT enhancer binding protein alpha;cyclic AMP responsive element binding protein;glial fibrillary acidic protein;Janus kinase 2;Ku antigen;laminin;microRNA 124;phosphatidylinositol 3 kinase;protein Jagged 1;protein p53;protein tyrosine phosphatase 1B;PUMA protein;regulatory factor X1;tau protein;transcription factor Sox;transcription factor Sox9;visinin;microRNA;MIRN124 microRNA, human;Alzheimer disease;angiogenesis;apoptosis;autophagy;blood brain barrier;brain ischemia;degenerative disease;down regulation;drug delivery system;endoplasmic reticulum stress;epilepsy;exosome;gene expression;human;Huntington chorea;hypoxic ischemic encephalopathy;MAPK signaling;memory;microglia;nerve cell differentiation;nerve cell plasticity;nerve degeneration;nerve excitability;nervous system inflammation;neurite outgrowth;neuroapoptosis;neuroprotection;neurotoxicity;nonhuman;Notch signaling;oxidative stress;Parkinson disease;Pi3K/Akt signaling;protein expression;protein phosphorylation;regulatory T lymphocyte;Review;upregulation;animal;apoptosis;brain injury;cerebrovascular accident;metabolism;oxidative stress;pathology;Alzheimer Disease;Animals;Apoptosis;Autophagic Cell Death;Brain Injuries;Brain Ischemia;Humans;MicroRNAs;Oxidative Stress;Stroke
期刊:
International Journal of Molecular Sciences
ISSN:
1661-6596
年:
2020
卷:
21
期:
1
页码:
120
基金类别:
Author Contributions: Z.M. conceived the review, drafted partly, and revised the manuscript. X.L. and Z.F. reviewed all the literature, collected data, and drafted the manuscript, L.D. and Y.H. gave some positive Author Contributions: Z.M. conceived the review, drafted partly, and revised the manuscript. X.L. and Z.F. suggestions for the English language; J.G. and Y.D. provided valuable critical revisions of the manuscript. All for the English language; J.G. and Y.D. provided valuable critical revisions of the manuscript. All authors approved the final version of the manuscript. All authors have read and agreed to the published version of the manuscript. Funding: This researchwas funded by YichangScienceand TechnologyPlan ProjectsinHubei Province,China Fun(Ndoin. Ag:1T9-h3i0s1r-e4s2e; aNrcoh. Aw1a8s-3f0u2n-ad1e2d).by Yichang Science and Technology Plan Projects in Hubei Province, China (No. A19-301-42; No. A18-302-a12). Acknowledgments: We thank the financial support from the Yichang Science and Technology Plan Projects in Acknowledgments:Hubei Province, ChWina e thank(No. A19the-301financial-42; Nosupport. A18-302fr-a12om)the Yichang Science and Technology Plan Projects in Hubei Province, China (No. A19-301-42; No. A18-302-a12). Conflicts of Interest: The authors declare that they have no conflicts of interest. Conflicts of Interest: The authors declare that they have no conflicts of interest. This research was funded by Yichang Science and Technology Plan Projects in Hubei Province, China (No. A19-301-42; No. A18-302-a12). We thank the financial support from the Yichang Science and Technology Plan Projects in Hubei Province, China (No. A19-301-42; No. A18-302-a12).
机构署名:
本校为其他机构
摘要:
Cerebral ischemia injury, the leading cause of morbidity and mortality worldwide, initiates sequential molecular and cellular pathologies that underlie ischemic encephalopathy (IE), such as ischemic stroke, Alzheimer disease (AD), Parkinson’s disease (PD), epilepsy, etc. Targeted therapeutic treatments are urgently needed to tackle the pathological processes implicated in these neurological diseases. Recently, accumulating studies demonstrate that microRNA-124 (miR-124), the most abundant miRNA in brain tissue, is aberrant in peripheral blood ...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com