Saliva test is a kind of research popular in recent years. The biomarkers in saliva could reflect systemic health condition, it contains abundant bioinformations. Compared with urine specimen, saliva has the advantages of real-time sampling. Compared with the serum specimens, saliva collection is safe, noninvasive, no risk of spreading the blood-borne diseases, patients are easy to accept. Saliva test is becoming the most potential and application prospect in current noninvasive test field. Here it will be elaborated on the research progress in clinical diagnosis and therapeutic application, d...