Objective To optimize the conditions of the preparation technique of the Borneolum syntheticum liposme.Methods The optimum composition and preparation process of the liposome was selected with orthogonal design.The shape,size and size distribution were observed by scanning electron microscopy.Encapsulation efficiency was determined by centrifugation.Results The obtained liposome had a sphere shape with narrow size distribution,and higher encapsulation efficiency(89.9±1.0)%.Conclution The preparation method of the Borneolum s...