Objective In order to select the best alcohol extraction of Rhizoma corydalis. Methods Taking the indexes of Tetrahydropalmatine and extract alcohol solublility, the ethanol extraction technology of Rhizoma corydalis were optimizated with orthogonal design test. Results The best extraction process were thick powder, with 75% ethanol extract twice, first 9 times the amount of ethanol extraction for 1.5 h, second 7 times ethanol extraction of 1.0 h. Conclusion The process is simple and fe...